With Multiplicity I can easily move files/folders to the laptop that sits on one side of my desk before travel, and back again when I return to the office. I also keep a full backup system that mirrors my office desktop on a system in the basement. With KVM mode I can easily verify the system is properly synced, and all software updates are in-place without having to walk down to the basement from my 2nd floor office. I've used Remote Desktop, GoToMyPC and TeamViewer for remote system admin of my backup PC, but really prefer the simple KVM mode of Multiplicity. For controlling the laptop on my desk from the desktop I've used Mouse without Borders, and Synergy, but Multiplicity has more options, including the ability to share audio.